A real-world study undertaken by Public Health England in 14,019 people infected with the delta variant (B.1.617.2) in England found that vaccination with two doses of AstraZeneca and Pfizer offered high protection against hospitalisation. Of the 14,019 people infected with the delta variant, only 166 required hospitalisation. The study was undertaken between April 12 and June 4.
In the case of AstraZeneca, effectiveness against hospitalisation after full vaccination was 92%, while it was 96% in the case of Pfizer. The results have been posted as a preprint. Preprints are yet to be peer-reviewed.
Public Health England had earlier found that despite modest reductions, vaccines remain effective against the delta variant. It found that in the case of the delta variant, full vaccination offered good protection against symptomatic disease. Vaccine effectiveness against symptomatic disease was 67% in the case of AstraZeneca and 88% with Pfizer.
Effectiveness against hospitalisation was high even with one dose of AstraZeneca and Pfizer vaccine. In the case of delta variant, one dose of AstraZeneca vaccine offered 71% protection against hospitalisation, while two doses offered 92% protection. In the case of Pfizer vaccine, the protection against hospitalisation was 94% after one dose and 96% after two doses.
“These findings indicate very high levels of protection against hospitalisation with the delta variant with one or two doses of either vaccine,” the authors write. “Understanding the effectiveness against more severe end points such as hospital admissions is crucial in evaluating the risk delta variant poses on the population.”
“One dose effectiveness against hospitalisation [with delta variant] of the AstraZeneca vaccine was 71% and two doses were 92%. This is reassuring data for India. In order to choose our way forward, I think we should use modelling approaches that lay out different implementation strategies and compare their impact at different stages of the pandemic,” says Dr. Gagandeep Kang, Professor of Microbiology at CMC Vellore.